Science-Based Education · 74 Protocols

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peptide science

Everyone is talking about peptides. Very few people actually understand them.
Peptide Academy changes that — with clear, cited, welcoming education for curious minds and serious practitioners alike.

Start Learning Browse All 74 Protocols

Protocol Guides

600+

Research Citations

Learning Tracks

$25

Starts From

Featured Protocols

Recovery

Research

BPC-157

Body Protection Compound

Accelerates tendon, ligament, and gut repair via angiogenesis and growth factor upregulation.

TendonGutNeuro

Weight Loss

FDA Approved

Semaglutide

GLP-1 Receptor Agonist

Longevity

Research

NAD+

Nicotinamide Adenine Dinucleotide

+ 71 more protocols →

Peer-reviewed citations on every guide

FDA regulatory status clearly labeled

No ads, no affiliate links, no bias

Updated April 2026

Educational use only — not medical advice

Why Peptide Academy

You deserve better than a blog post

Peptides are one of the most searched health topics of 2026 — and also one of the most misunderstood. Reddit threads with bad advice. Influencer content pushing products. Clinical papers no one can read. We built the resource that should have existed years ago.

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Every claim is cited

PubMed links on every mechanism and dosing claim. No opinions dressed as facts.

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Designed for real humans

Beginner-friendly language without sacrificing scientific accuracy. Learn at your own pace.

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Complete, not curated

74 full protocol guides — not 10 popular ones. If it exists and matters, it's here.

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Honest about the unknowns

When human data is limited, we say so. When evidence is preclinical only, we say so.

Pick your track

Whether you've never heard of a peptide or you're a practitioner building protocols, there's a path designed for where you are right now.

🌱 Beginner

Peptide Foundations

Start here. Learn what peptides are, how they work, why they're different from supplements, and how to think about them safely.

What is a peptide? (vs. protein, vs. drug)

How peptides enter your body

FDA status — what it actually means

Reading a protocol document

Reconstitution 101

Start Learning

📖 Intermediate

Protocol Builder

Deep-dive into individual protocols. Understand mechanisms, dosing, stacking rationale, contraindications, and how to build goal-specific programs.

Recovery: Wolverine Stack mechanics

GH optimization: GHRH + GHRP synergy

GLP-1 class: comparing all options

Cognitive stacks: Semax + Selank

Stacking principles & timing

Explore Protocols

🔬 Advanced

Frontier Science

For practitioners and advanced researchers. Mitochondrial peptides, senolytics, triple GLP-1 agonists, IGF-1 LR3, follistatin, and cutting-edge longevity science.

Mitokines: SS-31, MOTS-C, Humanin

Senolytic therapy: FOXO4-DRI

Triple agonist weight loss (Retatrutide)

Advanced GH axis optimization

Bioregulator peptides (Khavinson)

Go Deep

Protocol Library

74 protocol guides

Mechanism · Dosing · Reconstitution · Stacking · Contraindications · References

Dosing Calculator

Reconstitution made simple

Pick a peptide, enter your weight and vial — get your exact draw volume, syringe units, and timing notes. Updates live as you adjust.

⚗️ Reconstitution Setup

Vial Size

Bacteriostatic Water

⏱ Timing: Load a peptide to see timing guidance.

💉 Your Draw

units on a U-100 syringe

Syringe fill level

0 25 50 75 100u

Dose 500mcg

Draw volume 0.50mL

Frequency 1× daily

Vial lasts 4days

Educational only · Not medical advice · Consult your provider

Stack Protocols

Peptides work better together

These are the most studied multi-peptide combinations — each one targeting a specific outcome with synergistic mechanisms explained.

Wolverine Recovery

The gold standard healing combination

BPC-157 drives local angiogenesis and gut healing. TB-500 mobilizes systemic stem cells and reduces inflammation. Together they cover every phase of tissue repair.

BPC-157TB-500

GLOW Aesthetic

Inside-out skin, hair, and tissue repair

Triple mechanism: angiogenesis (BPC-157) + cell migration (TB4) + collagen synthesis (GHK-cu). Most popular post-procedure aesthetic protocol.

BPC-157TB4GHK-cu

GH Optimization

3–10× amplified GH pulse

GHRH (CJC-1295) + GHRP (Ipamorelin) — two complementary mechanisms producing a synergistic GH pulse. The foundational anti-aging GH secretagogue protocol.

CJC-1295Ipamorelin

Metabolic Reset

Three fat-loss mechanisms in one

GLP-1 agonist for appetite suppression, AOD-9604 for direct lipolysis, MOTS-C for AMPK activation and fat browning. Three independent metabolic pathways.

GLP-1 RAAOD-9604MOTS-C

Nootropic Clarity

Sharp focus without the edge

Semax drives BDNF and dopaminergic focus. Selank provides GABA-mediated calm without sedation. NAD+ powers neurons. Balanced cognitive enhancement.

SemaxSelankNAD+

Longevity Protocol

Cellular rejuvenation from three angles

NAD+ replenishes coenzyme pools for sirtuin activation. SS-31 restores mitochondrial cristae. FOXO4-DRI selectively clears senescent cells.

NAD+SS-31FOXO4-DRI

Side-by-Side

Weight loss peptide comparison

How the major GLP-1 class compounds compare by evidence level, mechanism, and clinical outcomes.

Compound	Mechanism	Mean Weight Loss	Half-Life	FDA Status	Once Weekly
Semaglutide GLP-1 Receptor Agonist	GLP-1 RA	~15–17%	~7 days	FDA Approved	✓
Tirzepatide GLP-1 + GIP Dual Agonist	GLP-1+GIP RA	~22.5%	~5 days	FDA Approved	✓
Retatrutide Triple Agonist (GLP-1+GIP+Glucagon)	GLP-1+GIP+Glucagon	~24.2%	~6 days	Phase III	✓
AOD-9604 hGH Fragment 176-191	Direct lipolysis	Targeted fat	~30 min	Research	—
Cagrilintide Amylin Analogue	Amylin/Satiety	Additive (combo)	~7–8 days	Phase III	✓

Science Made Simple

Explained like you're twelve

Complex peptide science translated into everyday analogies. Tap any card to reveal the real science underneath.

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What is a peptide?

Your Body's Text Messages

"Peptides are like DMs your body sends between cells. Hormones are the long emails. Peptides are the quick texts — short, specific, and gone in minutes."

Peptides are chains of 2–50 amino acids linked by peptide bonds. Unlike large protein hormones, their small size allows rapid receptor binding and clearance. Synthetic peptides mimic endogenous signaling molecules — they speak the body's native biochemical language, binding specific receptors to trigger targeted downstream effects with minimal off-target activity.

Beginner

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Receptor Selectivity

The Lock and Key

"Every peptide has a shape. Every receptor is a lock. Ipamorelin only fits the GH lock — it can't accidentally open the cortisol door. That's why it has almost no side effects."

Peptide-receptor specificity is determined by tertiary structure. Ipamorelin's selectivity for GHS-R1a (ghrelin receptor) without activating ACTH or cortisol pathways distinguishes it from earlier GHRPs. This selectivity arises from its unique pentapeptide structure — Aib-His-D-2-Nal-D-Phe-Lys-NH₂ — which achieves high GH release with a markedly cleaner side-effect profile.

Beginner

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BPC-157 Mechanism

The Construction Foreman

"BPC-157 is the foreman on an injury site. It calls in three crews: plumbers (new blood vessels), electricians (nerve repair), and framers (tendon/collagen). TB-500 is the general contractor who shows up anywhere on the job site regardless of where you inject it."

BPC-157 promotes angiogenesis via VEGF upregulation and activates the FAK-paxillin pathway for accelerated cell migration. It modulates the NO system for gastroprotection and upregulates GH receptors in fibroblasts. TB-500 (Thymosin Beta-4) promotes systemic actin polymerization via its LKKTETQ domain, driving cell migration and stem cell mobilization regardless of injection site.

Recovery

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GH Peptides vs HGH

The Factory Shift

"Your pituitary is a factory running a GH shift every 90 minutes. Sermorelin rings the shift bell on time. Ipamorelin turns the volume up on each shift. MK-677 keeps the factory running around the clock. Exogenous HGH? That's importing finished product and bypassing the factory — which is why the feedback loop breaks."

GHRH analogs (Sermorelin, Tesamorelin, CJC-1295) stimulate pulsatile GH synthesis at the pituitary. GHRPs (Ipamorelin, GHRP-2) amplify GH pulse amplitude via ghrelin receptor agonism. Combined, they produce 3–10× amplification. Exogenous HGH suppresses endogenous GH via IGF-1 negative feedback on GHRH neurons and somatostatin upregulation — permanently altering axis sensitivity with prolonged use.

Growth Hormone

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GLP-1 / Semaglutide

The Laminated Note

"Your gut sends a 'we're full' note to your brain after eating. Normally that note disappears in 2 minutes. Semaglutide is the same note written on laminated paper — it lasts 7 days. Same message, same receptor, brain just can't forget it."

Native GLP-1 has a half-life of ~2 minutes due to DPP-4 cleavage. Semaglutide achieves ~7-day half-life through C18 fatty diacid conjugation enabling reversible albumin binding, plus two backbone modifications that confer DPP-4 resistance. It activates GLP-1R in the hypothalamic arcuate nucleus for appetite suppression and in pancreatic β-cells for glucose-dependent insulin secretion.

Weight Loss

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Reconstitution & Storage

The Opened Milk Rule

"Dry peptide powder is like powdered milk — shelf stable for months. Add bacteriostatic water and the clock starts, just like opening a carton of milk. 28 days in the fridge. After that, it's off. Label your vials like you'd date a leftover."

Lyophilized peptides are stable at room temperature for months (some years) due to removal of water that drives hydrolysis and oxidation. Reconstitution in bacteriostatic water (0.9% benzyl alcohol) provides antimicrobial preservation for multi-dose vials. Refrigeration at 2–8°C slows enzymatic degradation. Most peptides maintain ≥95% potency for 28–30 days reconstituted. Freeze-thaw cycles denature structure — never refreeze reconstituted peptides.

Beginner

Gear & Supplements